caliber has nothing to do with pricepoint. I sincerely recommend not going with a .22 if you are getting a handgun. There are some companies that have very afordable firearms in the higher calibers. I would refer you over to at least look at a Kel-Tec. Check out either the PF9, or the P11
^^^^that is the P11, which is a super-compact double stacked 9mm handgun that holds 12 rounds. and usually will run in the range of #250-$300.
or look into Rock Island Armory or Armscor 1911
^^^^Rock Island 1911, tons and tons of customizations, comes in 9mm and .45, and will run in the $300-$450 range depending on which model you go with because again, there are tons of mods for them, and they come in standard 8rd single stack, or high cap 17 rd double stack.....and the 9mm version single stack was hands down one of the best guns I had ever shot, action was smooth, barely any recoil, and it just looks awesome.
But do shop around and do some research, that is the key point, don't just go into a gun store and buy the first thing you think you may like. because the same guns will sometimes have much different pricepoints at different shops for one, and overall, you will want something that you will feel comfortable with.
I have a small tarus P22 and it is cute and fun to plink cans with.....but that is all it is good for....the ammo is cheap, so you can shoot a bunch and it wont hurt your pocket, but this being said, 9mm is not too bad on cost per box of ammo, so although it is preference, you may be better off going with a little higher caliber.
but be sure to follow the 4 golden rules of firearm safety at all times,
1. All guns are always loaded.
2. Never let the muzzle cover anything you are not willing to destroy.
3. Keep your finger off the trigger until your sights are on the target.
4. Be sure of your target and what is beyond it.
and be sure you have something you feel comfortable with.